Endothelial Cell Mechanotransduction in the Dynamic Vascular Environment
نویسندگان
چکیده
منابع مشابه
Dragging along: the glycocalyx and vascular endothelial cell mechanotransduction.
The glycocalyx is a complex and highly dynamic polymeric meshwork that coats the surfaces of most cells and consists of proteoglycans, glycosaminoglycans (GAGs), and glycoproteins, as well as adherent plasma proteins.1,2 In the microvasculature, the glycocalyx layer on the endothelial cell surface plays a critical role in regulating vessel permeability, modulating the dynamics of near-wall move...
متن کاملMechanotransduction in endothelial cell migration.
The migration of endothelial cells (ECs) plays an important role in vascular remodeling and regeneration. EC migration can be regulated by different mechanisms such as chemotaxis, haptotaxis, and mechanotaxis. This review will focus on fluid shear stress-induced mechanotransduction during EC migration. EC migration and mechanotransduction can be modulated by cytoskeleton, cell surface receptors...
متن کاملAnisotropic rheology and directional mechanotransduction in vascular endothelial cells.
Adherent cells remodel their cytoskeleton, including its directionality, in response to directional mechanical stimuli with consequent redistribution of intracellular forces and modulation of cell function. We analyzed the temporal and spatial changes in magnitude and directionality of the cytoplasmic creep compliance (Gamma) in confluent cultures of bovine aortic endothelial cells subjected to...
متن کاملMechanotransduction and endothelial cell homeostasis: the wisdom of the cell.
Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions. Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure and flow, modulate EC functions by activating mechanosensors, signaling pathways, and gene and protein expressions. Mechanical forces with a clear direction (e.g., the pulsatile shear stress and the uniaxial c...
متن کاملDynamic Regulation of Vascular Permeability by Vascular Endothelial Cadherin-Mediated Endothelial Cell-Cell Junctions.
Endothelial cells lining blood vessels regulate vascular barrier function, which controls the passage of plasma proteins and circulating cells across the endothelium. In most normal adult tissues, endothelial cells preserve basal vascular permeability at a low level, while they increase permeability in response to inflammation. Therefore, vascular permeability is tightly controlled by a number ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Biosystems
سال: 2018
ISSN: 2366-7478,2366-7478
DOI: 10.1002/adbi.201800252